منابع مشابه
Immunodeficiency: Trapping the nude mouse gene
Hairless nude mice are immunodeficient because they lack a thymus. The nude gene has now been identified; it encodes a winged-helix transcription factor that is expressed specifically in skin and thymus.
متن کاملTumorigenicity of Esophageal Cancer Stem Cells (ECSCs) in nude mouse xenograft model
Background and objectives: Modeling cancer in vivo is a very important tool to investigate cancer pathogenesis and molecular mechanisms involved in cancer progression. Laboratory mice are the most common animal used for rebuilding human cancer in vivo. Cancer stem cells (CSCs) are the main reason of failure in cancer therapy because of tumor relapse and metastasis. Isolation of cancer stem cell...
متن کاملHeterotransplantation of retinoblastoma into the athymic "nude" mouse.
Fresh surgical specimens of retinoblastoma were successfully transplanted into the anterior chamber of the "nude" mouse (a homozygous mutant, nu/nu, with a severe defect in cellular immunity), filling the eyes but failing to grow subcutaneously. Retinoblastoma cells from an established cell line, Y-79,1 spread from the intraocular injection site to invade the orbit, optic nerve, and brain and f...
متن کاملHeterotransplantation of human choroidal melanoma into the athymic "nude" mouse.
The investigation of the structure and behavior of malignant melanoma of the uveal tract in man has been limited by the lack of a ready source of human tumor and an animal model in which the tumor resembles that in the human choroid. We now report the observation that fresh surgical specimens of human choroidal melanoma can be successfully transplanted into the posterior segment of the "nude" m...
متن کاملA zebrafish orthologue (whnb) of the mouse nude gene is expressed in the epithelial compartment of the embryonic thymic rudiment
The cloning and characterization of the zebrafish orthologue of the mouse nude (Whn/Foxn1) gene, whnb are reported. A previously described Whn-like gene from zebrafish, now designated as whna, is shown to be the orthologue of the mouse Foxn4 gene. The whnb gene is specifically expressed in the thymic rudiment of zebrafish embryos at day 3 after fertilization, whereas the whna gene is expressed ...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2015
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.1403061